The Proteome of Postsurgical Pancreatic Juice

The protein composition of human pancreatic juice.

1. Human pancreatic juice contains amylase, lipase, ribonuclease, deoxyribonuclease, proelastase, procarboxypeptidase A, procarboxypeptidase B, chymotrypsinogen, and trypsinogen, as well as a tqqsin inhibitor. The level of the inhibitor is such that 1 ml of pancreatic juice containing 4 mg of protein will inhibit about 0.08 mg of bovine trypsin. The inhibitor is a small, basic protein, soluble ...

The proteins of bovine pancreatic juice.

In the years since the classical work of Northrop and Kunitz on the isolation and characterization of the pancreatic proteins, trypsinogen and chymotrypsinogen-cy (I), an impressive body of knowledge has accumulated about these and other pancreatic proteins. The proteins which have been isolated in crystalline form from the pancreas gland now include trypsinogen, trypsin, chymotrypsinogens a! a...

Identification of pancreatic juice proteins as biomarkers of pancreatic cancer.

Pancreatic juice is a potential source of proteins associated with pancreatic cancer (PC) due to the proximity of ducts to tumor tissue. Therefore, screening of proteins in pancreatic juice from PC patients may identify new PC biomarkers. We analyzed pancreatic juice from patients with pancreatic diseases including PC, chronic pancreatitis (CP) and simple choledocholithiasis (CDS) by 2-DE. Prot...

Analysis of human pancreatic juice in tests of pancreatic function.

Carboxylic ester hydrolases of rat pancreatic juice.

An attempt was made to establish the number and characteristics of the enzymes in pancreatic juice that hydrolyze nitrogen- and phosphorus-free esters of fatty acids. For this purpose model compounds were hydrolyzed by lyophilized rat pancreatic juice under conditions that accelerated or inhibited the reactions. Although it is not established with certainty, it is suggested that three enzymes a...